This isn't the Scooby-Doo that you grew up with. This is the end of the world as we know it.
The characters have the same appearance, names, and similar personalities, but they are in a different setting. Daphne has a cable show investigating mysteries and Freddy is her cameraman. Shaggy is a dog trainer and works in a military "smart dog" experiment, and Scooby is one of the project's dogs. Velma is a PhD researcher with the project. And the Mystery Machine is a pet project of one of the researchers and is more like the APC from the movie "Aliens" than the groovy van from the Saturday morning cartoons.
When all the characters come together, they discover that a plague of sorts has been released and is mutating people around the world. And the sad part is, the cause of the plague was supposed to "better" humanity (shades of "Serenity"), but instead folks have different reactions, becoming strange creatures. Between the mutants roaming around, the breakdown of civilization, and the pack of other "smart dogs" that escape from the military complex, the gang will have a hard time staying alive - much less finding a cause and a cure.
Revamped for a new generation of fans with a level of violence and gore best suited to ages 12+. Those readers will also be mature enough to understand the concepts of conspiracy, suspicion, pursuing ideals, and the sarcastic humor. A favorite example: Velma, "Please! This isn't a comic book!" Shaggy, "It's sure starting to feel like one."
I read an e-book provided by the publisher through NetGalley.